Flinderoles A−C: Antimalarial Bis-indole Alkaloids from Flindersia Species
Organic Letters2008Vol. 11(2), pp. 329–332
Citations Over TimeTop 10% of 2008 papers
Liza S. Fernandez, Malcolm S. Buchanan, Anthony R. Carroll, Yunjiang Feng, Ronald J. Quinn, Vicky M. Avery
Abstract
With the aim of finding new natural product antimalarials, the novel indole alkaloids flinderole A-C were found to have selective antimalarial activities with IC(50) values between 0.15-1.42 microM. Flinderole A was isolated from the Australian plant Flindersia acuminata and flinderoles B and C from the Papua New Guinean plant F. amboinensis. Flinderoles A-C contain an unprecedented rearranged skeleton compared to their related isomers of the borreverine class of compounds.
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