A Zn2+ Fluorescent Sensor Derived from 2-(Pyridin-2-yl)benzoimidazole with Ratiometric Sensing Potential
Organic Letters2009Vol. 11(4), pp. 795–798
Citations Over TimeTop 10% of 2009 papers
Zhipeng Liu, Changli Zhang, Yunling Li, Zhengyi Wu, Fang Qian, Xiaoliang Yang, Weijiang He, Xiang Gao, Zijian Guo
Abstract
A fluorescent Zn(2+) sensor based on the 2-(2'-pyridinyl)benzoimidazole (2-PBI) fluorophore has been devised by incorporation with a Zn(2+) ionophore, bis(pyridin-2-ylmethyl)amine. The sensor (PBITA) demonstrates a Zn(2+)-specific emission shift and enhancement with a 1:1 binding ratio. Due to the Zn(2+)-induced coplanation of 2-PBI via reversion/rotation, PBITA is shown to behave as a ratiometric sensor. The intracellular Zn(2+) imaging ability of the sensor has been tested in HeLa cells using a confocal microscope.
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