Nickel-Catalyzed Oxidative Coupling Reactions of Two Different Terminal Alkynes Using O2 as the Oxidant at Room Temperature: Facile Syntheses of Unsymmetric 1,3-Diynes
Organic Letters2008Vol. 11(3), pp. 709–712
Citations Over TimeTop 10% of 2008 papers
Abstract
Two different terminal alkynes now can be coupled together in the presence of NiCl(2).6H(2)O/CuI by using an excess of one of the terminal alkyne substrates. The new method employed 20 mol % TMEDA as the ligand and environmentally benign O(2) or air as the oxidant. It is the first example using Ni-salt as catalyst by employing air or O(2) as oxidant, which led to efficient heterocoupling of two different alkynes.
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