Synthesis of Fish Antifreeze Neoglycopeptides Using Microwave-Assisted “Click Chemistry”
Organic Letters2009Vol. 11(11), pp. 2409–2412
Citations Over TimeTop 10% of 2009 papers
Abstract
Microwave-enhanced click glycoconjugation of a propargylated alpha-GalNAc sugar moiety with an azido-functionalized amino acid or multiazido-functionalized peptides using a catalytic quantity of Cu(I) enabled a high-yielding and rapid synthesis of a "Tn-antigen mimic" and click analogues of antifreeze glycopeptides, thus demonstrating a valuable synthetic platform for the synthesis of biologically relevant neoglycopeptides.
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