Secondary Amine Formation from Reductive Amination of Carbonyl Compounds Promoted by Lewis Acid Using the InCl3/Et3SiH System
Organic Letters2009Vol. 11(15), pp. 3302–3305
Citations Over TimeTop 10% of 2009 papers
Abstract
A robust and reliable method has been developed for reductive amination of primary amines with various aldehydes and ketones using Zn(ClO(4))(2) x 6 H(2)O as a catalyst. [In-H] generated in situ via a combination of InCl(3) and Et(3)SiH is employed as an effective reducing system. A variety of secondary amines can be synthesized in a one-pot procedure in excellent yields.
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