Highly Selective and Sensitive Heparin Probing from Supramolecular Assembly of Pyrene Derivatives
Organic Letters2009Vol. 11(19), pp. 4294–4297
Citations Over TimeTop 10% of 2009 papers
Abstract
A new quinine derivative PQ, bearing pyrenyl as a fluorophore, was prepared to recognize heparin in aqueous solution. PQ exhibits good selectivity and sensitivity for heparin over other biological molecules. Upon binding with heparin, PQ shows a typical excimer emission peaked at 489 nm along with a weak monomer emission at 376 nm. Moreover, PQ also shows good performance to detect the heparin in serum.
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