Swerilactones A and B, Anti-HBV New Lactones from a Tradtional Chinese Herb: Swertia mileensis as a Treatment for Viral Hepatitis
Organic Letters2009Vol. 11(18), pp. 4120–4123
Citations Over TimeTop 11% of 2009 papers
Chang‐An Geng, Zhiyong Jiang, Yun‐Bao Ma, Jie Luo, Xue‐Mei Zhang, Hongling Wang, Yong Shen, Ai‐Xue Zuo, Jun Zhou, Ji‐Jun Chen
Abstract
Swerilactones A (1) and B (2), two novel lactones with an unprecedented 6/6/6/6/6 pentacyclic ring system, were isolated from the traditional Chinese herb of Swertia mileensis with activity against the hepatitis virus. Their structures and relative stereochemistry were elucidated based on spectroscopic methods and further confirmed by X-ray single crystal diffraction analysis. In vitro antihepatitis B virus (HBV) assay on Hep G 2.2.15 cell line showed that compound 1 inhibited HBsAg and HBeAg secretion with IC(50) values of 3.66 and 3.58 mM, respectively.
Related Papers
- → Experimental study of the inhibitory effect of gantai capsule on HBsAg and HBeAg expression(2002)1 cited
- Inhibition of HBsAg and HBeAg Expression by ASODN of Various Regions of the HBV Genome(2005)
- Inhibitory effect of extracts of the core of lithion the expression of HBsAg and HBeAg in the HepG 2.2.15 cells(2004)
- Inhibitory effect of FFYC tablets(FFYC) on expression of HBsAg and HBeAg(2004)
- Experimental Study of the Inhibitory Effect of Gantai Capsule (肝泰胶囊) on HBsAg and HBeAg Expression(2002)