Swerilactones C and D, anti-HBV New Lactones from a Traditional Chinese Herb: Swertia mileensis
Organic Letters2009Vol. 11(21), pp. 4838–4841
Citations Over TimeTop 10% of 2009 papers
Chang‐An Geng, Xue‐Mei Zhang, Yong Shen, Ai‐Xue Zuo, Jifeng Liu, Yun‐Bao Ma, Jie Luo, Jun Zhou, Zhi‐Yong Jiang, Ji‐Jun Chen
Abstract
Swerilactones C (1) and D (2), two novel diastereomeric lactones with an unprecedented 6/6/6/6/6 pentacyclic ring system, were isolated from the traditional Chinese herb Swertia mileensis. Their structures and relative stereochemistry were elucidated on the basis of spectroscopic methods and further confirmed by X-ray single-crystal diffraction analysis. In vitro antihepatitis B virus (HBV) assay on the Hep G 2.2.15 cell line showed that both compounds 1 and 2 exhibited inhibitory activities against the secretion of HBsAg (IC(50) = 1.24 and 2.96 mM, respectively) and HBeAg (IC(50) = 0.77 and 1.47 mM, respectively).
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