Intermolecular Decarboxylative Direct C-3 Arylation of Indoles with Benzoic Acids
Organic Letters2009Vol. 11(23), pp. 5506–5509
Citations Over TimeTop 1% of 2009 papers
Abstract
A palladium catalyzed C-H activation of indoles and a silver catalyzed decarboxylative C-C activation of ortho substituted benzoic acids are synergistically combined to synthesize indoles arylated exclusively in the C-3 position. This novel decarboxylative C-H arylation methodology is compatible with electron-donating and -withdrawing substituents in both coupling partners.
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