Alasmontamine A, A First Tetrakis Monoterpene Indole Alkaloid from Tabernaemontana elegans
Organic Letters2009Vol. 11(24), pp. 5718–5721
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Yusuke Hirasawa, Saori Miyama, Takahiro Hosoya, Koichiro Koyama, Abdul Rahman, Idha Kusumawati, Noor Cholies Zaini, Hiroshi Morita
Abstract
A novel tetrakis monoterpene indole alkaloid, alasmontamine A (1) consisting of bis-vobtusine-type skeletons, was isolated from the leaves of Tabernaemontana elegans. The structure including the relative stereochemistry was elucidated on the basis of spectroscopic data. Alasmontamine A (1) exhibited moderate cell growth inhibitory activity against HL-60 cells.
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