Novel, Tunable, and Efficient Chiral Bisdihydrobenzooxaphosphole Ligands for Asymmetric Hydrogenation
Organic Letters2009Vol. 12(1), pp. 176–179
Citations Over TimeTop 10% of 2009 papers
Wenjun Tang, Bo Qu, Andrew G. Capacci, Sonia Rodrı́guez, Xudong Wei, Nizar Haddad, Bikashandarkoil Narayanan, Shengli Ma, Nelu Grinberg, Nathan K. Yee, Dhileep Krishnamurthy, Chris H. Senanayake
Abstract
A series of novel, efficient, air-stable, and tunable chiral bisdihydrobenzooxaphosphole ligands (BIBOPs) were developed for rhodium-catalyzed hydrogenations of various functionalized olefins such as alpha-arylenamides, alpha-(acylamino)acrylic acid derivatives, beta-(acylamino)acrylates, and dimethyl itaconate with excellent enantioselectivities (up to 99% ee) and reactivities (up to 2000 TON).
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