Phosphine-Mediated Stereoselective Reductive Cyclopropanation of α-Substituted Allenoates with Aromatic Aldehydes
Organic Letters2010Vol. 12(3), pp. 544–547
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Abstract
A novel phosphine-mediated reductive cyclopropanation between alpha-substituted allenoates 2 and aldehydes 1 is described. It represents a new member of the allene-based annulations, which provides facile and efficient access to highly functionalized cyclopropanes 3 from simple and readily available starting materials. It also unveils an unprecedented reactivity pattern of allenoates with aldehydes.