Catalytic Enantioselective Amination of Enolsilanes Using C2-Symmetric Copper(II) Complexes as Chiral Lewis Acids
Organic Letters1999Vol. 1(4), pp. 595–598
Citations Over TimeTop 10% of 1999 papers
Abstract
[formula: see text] [Cu(S,S)-t-Bu-box](OTf)2 (1) catalyzes the enantioselective amination of enolsilanes with azodicarboxylate derivatives. Isomerically pure enolsilanes of aryl ketones, acylpyrroles, and thioesters added to the azo-imide in greater than 95% ee. The use of an alcohol additive was critical to achieving catalyst turnover.
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