Absolute Configuration of Novel Bioactive Flavonoids from Tephrosia purpurea
Organic Letters2000Vol. 2(4), pp. 515–518
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Leng Chee Chang, Daniel Chávez, Lynda L. Song, Norman R. Farnsworth, John M. Pezzuto, A. Douglas Kinghorn
Abstract
[structure: see text] Three novel flavonoids, (+)-tephrorins A (1) and B (2) and (+)-tephrosone (3), were isolated from Tephrosia purpurea. Their structures were elucidated by NMR spectral analysis, and their absolute configurations were determined by Mosher ester methodology. Compounds 1 and 2 are flavanones containing an unusual tetrahydrofuran moiety. Compounds 1-3 were evaluated for their potential cancer chemopreventive properties using a cell-based quinone reductase induction assay.
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