Rhodium-Catalyzed [5 + 2] Cycloadditions of Allenes and Vinylcyclopropanes: Asymmetric Total Synthesis of (+)-Dictamnol
Organic Letters1999Vol. 1(1), pp. 137–140
Citations Over TimeTop 10% of 1999 papers
Abstract
The asymmetric synthesis of (+)-dictamnol is described, based on the rhodium catalyzed [5 + 2] cycloaddition of an allene and vinylcyclopropane. This cycloaddition methodology provides the basis for a general and efficient route to various bicyclo[5.3.0]decenes, ring systems common to a wide range of natural and designed compounds of structural and medicinal interest.
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