Modular Nucleic Acid Surrogates. Solid Phase Synthesis of α-Helical Peptide Nucleic Acids (αPNAs)
Organic Letters1999Vol. 1(3), pp. 403–406
Citations Over Time
Abstract
[formula: see text] The synthesis and characterization of prototype alpha-helical peptide nucleic acid (alpha PNA) modules 1-3 as well as disulfide dimers 4 and 5 are reported. These molecules combine an alpha-helical peptidyl scaffold with well-defined nucleobase molecular recognition patterns and could serve as a basis for novel antisense and/or antigene agents. Structure assignments for these alpha PNAs were supported by MALDI-TOF mass spectrometry, and the alpha-helical nature of 4 in water was confirmed by circular dichroism (CD) spectroscopy.
Related Papers
- → Solution structure of a peptide nucleic acid–DNA duplex(1996)206 cited
- → Thermal Stability of Peptide Nucleic Acid Complexes(2019)36 cited
- → Peptide nucleic acid (PNA) with a chiral backbone based on alanine(1994)79 cited
- → Fluoroaromatic universal bases in peptide nucleic acids(2002)22 cited
- Peptide nucleic acid array(2003)