Antimitotic Diterpenes from Erythropodium caribaeorum Test Pharmacophore Models for Microtubule Stabilization
Organic Letters2000Vol. 2(3), pp. 257–260
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Bruno Cinel, Michel Roberge, Hans W. Behrisch, Leen van Ofwegen, Clovis B. Castro, Raymond J. Andersen
Abstract
[structure: see text] Six new antimitotic diterpenes, 2-7, have been isolated from the Caribbean octocoral Erythropodium caribaeorum. Structural variations encountered in this group of natural products test recently proposed pharmacophore models for microtubule stabilizing compounds.
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