Combined Experimental and Computational Investigation of the Mechanism of Nickel-Catalyzed Three-Component Addition Processes
Organometallics2004Vol. 23(20), pp. 4636–4646
Citations Over TimeTop 10% of 2004 papers
Hrant P. Hratchian, Sanjoy K. Chowdhury, Víctor Manuel Gutiérrez‐García, Kande K. D. Amarasinghe, Mary Jane Heeg, H. Bernhard Schlegel, John Montgomery
Abstract
The mechanism of nickel-catalyzed couplings of an enone, alkyne, and organozinc has been studied. Adducts of the substrates with nickel(0) have been isolated and characterized, and their reactivity was examined. A potential intermediate was demonstrated to not be kinetically competent in catalytic cyclizations. A computational approach employing the B3LYP density functional method and the 6-31G(d) basis set was used to examine mechanistic possibilities that were consistent with experimental observations, and a modified mechanism for the catalytic cyclizations was formulated. The newly proposed mechanism involves production of an active catalyst that involves a novel interaction between Ni(0) and dimethylzinc.
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