Synthesis and Characterization of Gold(I) N-Heterocyclic Carbene Complexes Bearing Biologically Compatible Moieties
Organometallics2006Vol. 25(24), pp. 5824–5828
Citations Over TimeTop 10% of 2006 papers
Abstract
Two new gold(I) complexes bearing the bulky N-heterocyclic carbene IPr (IPr = bis(2,6-diisopropylphenyl)imidazol-2-ylidene) and respectively 2,3,4,6-tetra-O-acetyl-1-thio-β-d-pyranosatothiolato [(IPr)AuTgt (1)] and a saccharin ligand [(IPr)AuSac (2)] have been synthesized in good yield and are fully characterized by NMR spectroscopy and by inert-atmosphere MALDI-TOF. These complexes are well-behaved compounds analogous to gold drugs such as Auranofin and Solganol.
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