Diastereo- and Enantioselective Construction of Oxindole-Fused Spirotetrahydrofuran Scaffolds through Palladium-Catalyzed Asymmetric [3+2] Cycloaddition of Vinyl Cyclopropanes and Isatins
Organometallics2013Vol. 32(12), pp. 3544–3556
Citations Over TimeTop 10% of 2013 papers
Abstract
A novel asymmetric formal [3+2] cycloaddition of vinyl cyclopropanes and isatins in the presence of Pd2(dba)3 and the chiral imidazoline-phosphine ligand (aS,R,R)-L3 has been developed, affording the corresponding highly functionalized oxindole-fused spirotetrahydrofuran frameworks in good yields along with good diastereo- and high enantioselectivities under mild conditions.
Related Papers
- → Catalytic Enantioselective Total Synthesis of Hodgkinsine B(2011)74 cited
- → Enantioselective palladium-catalyzed C(sp2)-H carbamoylation(2019)25 cited
- → Enantioselective palladium catalyzed allylic substitution with new chiral pyridine-phosphine ligands(1997)46 cited
- → Hydrogenation catalysts containing phosphine complexes of palladium bound to silica(1975)4 cited
- → Bis(pentachlorophenyl) derivatives of palladium(II)(1977)18 cited