Well-Defined N-Heterocyclic Carbene Based Ruthenium Catalysts for Direct Amide Synthesis from Alcohols and Amines

Citations Over TimeTop 10% of 2010 papers

Abstract

Well-defined N-heterocyclic carbene based ruthenium complexes were developed as highly active catalysts for direct amide synthesis from alcohols and amines. A catalytic amount of a base such as KOtBu was essential to initiate the catalytic cycle. Activity of the Ru complexes was comparable with the reported in situ Ru catalysts. These catalysts provided mechanistic insight suggesting a Ru hydride species as an active catalytic intermediate. The generation of the Ru hydride was critical for the amidation of free aldehydes.

Related Papers

• → A Stable Four-Membered N-Heterocyclic Carbene(2004)139 cited
• → Ligand control of metal oxidation states. Synthesis, characterization and cyclic voltammetric studies of a group of ruthenium phenolates(1996)18 cited
• THE FEATURES OF PROTEIN BINDING BY RUTHENIUM COMPLEXES: DOCKING, FORCE FIELD AND QM/MM STUDIES(2013)
• → Phosphorogenic and spontaneous formation of tris(bipyridine)ruthenium in peptide scaffolds(2019)1 cited
• → ChemInform Abstract: Synthesis, Reactivities, and Structural Studies on High‐Valent Ruthenium Oxo Complexes. Ruthenium(IV), Ruthenium(V), and Ruthenium(VI) Oxo Complexes of Tertiary Amine Ligands.(1987)