Development of a Practical, Safe, and High-Yielding Process for the Preparation of Enantiomerically Pure trans-Cyclopropane Carboxylic Acid
Organic Process Research & Development2002Vol. 6(5), pp. 618–620
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Ambarish K. Singh, Meena Rao, James H. Simpson, Wen-Sen Li, John E. Thornton, Daniel Kuehner, David J. Kacsur
Abstract
A practical, safe, and high-yielding process for the cyclopropanation of a chiral epoxide has been developed using the inexpensive and nonhazardous reagents triethylphosphonoacetate and sodium tert-butoxide.
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