A Practical Synthesis of l-Valyl-pyrrolidine-(2R)-boronic Acid: Efficient Recycling of the Costly Chiral Auxiliary (+)-Pinanediol
Organic Process Research & Development2002Vol. 6(6), pp. 814–816
Citations Over TimeTop 24% of 2002 papers
Frank S. Gibson, Ambarish K. Singh, Maxime Soumeillant, Percy S. Manchand, Michael Humora, David R. Kronenthal
Abstract
A practical synthesis of l-valyl-pyrrolidine-(2R)-boronic acid (1) is detailed. A previously disclosed synthesis of 1 (Snow, R.; Kelly, T. R.; Adams, J.; Coutts, S.; Perry, C. (Boehringer Ingelheim Pharmaceuticals, Inc.). WO 93/10127, 1993) was significantly improved by developing an efficient process for recycling the costly chiral auxiliary (+)- pinanediol.
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