Large-Scale Synthesis of the Anti-Cancer Marine Natural Product (+)-Discodermolide. Part 3: Synthesis of Fragment C15-21
Organic Process Research & Development2003Vol. 8(1), pp. 107–112
Citations Over TimeTop 11% of 2003 papers
Stuart J. Mickel, Gottfried Sedelmeier, Daniel Niederer, Friedrich Schuerch, Guido Koch, Ernst Kuesters, Robert Daeffler, Adnan Osmani, Manuela Seeger‐Weibel, Emil Schmid, Alfred Hirni, Karl Schaer, Remo Gamboni, Andrew Bach, Stephen Chen, Wei‐Chun Chen, Peng Geng, Christopher T. Jagoe, Frederick R. Kinder, George T. Lee, Joseph McKenna, Timothy M. Ramsey, Oljan Repič, Larry Rogers, Wen‐Chung Shieh, Run-Ming Wang, Liladhar Waykole
Abstract
Smith's procedure of preparing fragment C15-21 (5) from common precursor 3 was optimized. The ease of plant operations made this six-step route successful for the production of several kilograms of this fragment with high purity.
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