Integrated Approach to the Development and Understanding of the Borane Reduction of a Carboxylic Acid
Organic Process Research & Development2004Vol. 8(6), pp. 1072–1075
Citations Over TimeTop 23% of 2004 papers
Abstract
A delayed exotherm was recorded during the reduction of a carboxylic acid with BH3·THF. This article will describe our efforts to explain and control the observed exotherm using a reactor integrated with a mass-flow meter, a reaction calorimeter, and an in situ FT-IR probe. In the end, a kinetic model is proposed that allows control of the addition rate of the reagent based on the known cooling capacity of the reaction vessel.
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