First Scale-Up to Production Scale of a Ring Closing Metathesis Reaction Forming a 15-Membered Macrocycle as a Precursor of an Active Pharmaceutical Ingredient
Organic Process Research & Development2005Vol. 9(4), pp. 513–515
Citations Over TimeTop 10% of 2005 papers
Abstract
BILN 2061 ZW (4) is a new chemical entity which shows promising results against the Hepatitis C virus. The major issue in the synthetic route represents the scale-up of a ring closing metathesis reaction to form a 15-membered macrocycle. The parameters chosen for the macrocyclization are discussed, and the experience during large scale synthesis, trouble shooting, and possible improvements for future campaigns are described.
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