Design of an Integrated Process of Chromatography, Crystallization and Racemization for the Resolution of 2′,6′-Pipecoloxylidide (PPX)
Organic Process Research & Development2012Vol. 16(2), pp. 343–352
Citations Over TimeTop 24% of 2012 papers
Jan von Langermann, Malte Kaspereit, Mozaffar Shakeri, Heike Lorenz, M. Hedberg, Matthew J. Jones, Kerstin Larson, Björn Herschend, Robert Arnell, Erik Temmel, Jan‐Erling Bäckvall, Achim Kienle, Andreas Seidel‐Morgenstern
Abstract
An integrated process for the chiral separation of the industrially relevant substance 2′,6′-pipecoloxylidide (PPX), an intermediate in the manufacture of a number of anesthetics, was developed. By combining three different techniques, chromatography, crystallization, and racemization, high productivity was achieved. All unit operations were executed using a common solvent system, full recycling, and a minimum of solvent exchanges or removals. The target molecule was obtained with an enantiopurity of >99.5 wt %.
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