Development of Continuous Anti-Solvent/Cooling Crystallization Process using Cascaded Mixed Suspension, Mixed Product Removal Crystallizers
Organic Process Research & Development2012Vol. 16(5), pp. 915–924
Citations Over TimeTop 10% of 2012 papers
Abstract
This paper describes a two-stage mixed-suspension, mixed-product removal (MSMPR) continuous crystallization developed for a pharmaceutical intermediate which uses anti-solvent and cooling to generate supersaturation. The results indicate that the stage in which anti-solvent is added has a significant influence on the final crystal properties, while purity and yield were nearly identical. The population balance model was employed to determine growth and nucleation kinetics through parameter estimation. With the incorporation of measured equilibrium distribution coefficients, the model was used to optimize crystal purity and yield of the product with respect to operating temperature and residence time.
Related Papers
- → Prediction of Residence Time Distribution of Stirred Reactors(2001)26 cited
- → Various Approaches to Compute Fluid Residence Time in Mixing Systems(2010)7 cited
- STUDY OF RESIDENCE TIME OF DISPERSE MATERIALS IN CONTINUOUSLY OPERATING FLUIDIZED BED APPARATUS(2013)
- → Residence time distribution studies on recycle reactor with recirculation(2021)4 cited
- Residence Time Distribution of Particles in Multi-Stage Fluidized Bed(1965)