The Development of a Scalable, Chemoselective Nitro Reduction
Organic Process Research & Development2012Vol. 16(10), pp. 1665–1668
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Abstract
We have demonstrated a scalable chemoselective reduction of a nitro functional group in the presence of an aryl imine using (NH4)2S/EtOH or hydrogenation (Sponge Nickel) to afford the corresponding amino-imines in moderate to excellent yields. Other reducible groups such as aryl halides, styryl olefins, and ether linkages survived as well.
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