Large-Scale Applications of Amide Coupling Reagents for the Synthesis of Pharmaceuticals
Organic Process Research & Development2015Vol. 20(2), pp. 140–177
Citations Over TimeTop 1% of 2015 papers
Abstract
This review showcases various coupling reagents which have been implemented specifically for large-scale amide synthesis via the condensation of an acid and amine, while highlighting the benefits and drawbacks of each reagent on an industrial scale.
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