Microscale HPLC Predicts Preparative Performance at Millionfold Scale
Organic Process Research & Development2008Vol. 12(4), pp. 674–677
Citations Over TimeTop 18% of 2008 papers
Christopher J. Welch, Peter Sajonz, Glenn Spencer, William R. Leonard, Derek Henderson, Wes Schafer, Frank Bernardoni
Abstract
The use of microscale HPLC for piloting the large-scale preparative chromatographic resolution of the enantiomers of a chiral pharmaceutical intermediate is reported with an example of a millionfold scale-up from a 300 μm i.d. column to a 30 cm i.d column. Performance and productivity at scale are accurately predicted by the microscale approach, which consumes only a small fraction of the material typically used for conventional loading studies. These results suggest a great potential for use of microscale HPLC loading studies during early synthetic route investigations, when only a small amount of sample is typically available.
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