Process Development for A Novel Pleuromutilin-Derived Antibiotic
Organic Process Research & Development2009Vol. 13(4), pp. 729–738
Citations Over TimeTop 10% of 2009 papers
Yemane W. Andemichael, Jun Chen, Jacalyn S. Clawson, Wenning Dai, Ann M. Diederich, Susan V. Downing, Alan J. Freyer, Peng Liu, Lynette M. Oh, Daniel B. Patience, Sonja Sharpe, Joseph Sisko, Julie Tsui, Frederick G. Vogt, June Wang, Lori A. Wernersbach, Edward C. Webb, James Wertman, Leon Zhou
Abstract
A scalable synthesis of a novel pleuromutilin-based antibiotic is reported. The synthesis features the scale-up of an interesting skeletal rearrangement of the pleuromutilin core and isolation of a highly purified product despite starting with relatively impure pleuromutilin. The use of Design of Experiment (DoE) and Principal Component Analysis (PCA) tools to achieve these goals is also discussed. Furthermore, the novel coupling of a carbamate and N-acyl-imidazole to produce the imidodicarbonate portion of the target molecule is described.
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