Investigation of Synthetic Routes to a Key Benzopyran Intermediate of a 5HT4 Agonist
Organic Process Research & Development2009Vol. 14(1), pp. 92–98
Citations Over Time
Gerasimos Rassias, Neil G. Stevenson, Neil R. Curtis, John M. Northall, Matthew Gray, Jeremy C. Prodger, Andrew J. Walker
Abstract
The supply route to GlaxoSmithKline’s 5HT4 receptor agonist 1 centred on the construction of key benzopyran fragment 2. Our attempts to define the final manufacturing route for this component are described through a series of disconnections. The systematic approach undertaken towards the construction of the benzopyran skeleton focused on cyclisation strategies from appropriate precursors and evaluation of the performance of the key steps.
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