Exploring the Scope for Scale-Up of Organic Chemistry Using a Large Batch Microwave Reactor
Organic Process Research & Development2010Vol. 14(1), pp. 205–214
Citations Over TimeTop 10% of 2010 papers
Abstract
A new batch microwave reactor has been evaluated in the context of palladium-mediated transformations, condensation reactions, nucleophilic aromatic substitution reactions, and alkylations. Importantly, a linear scaling approach was taken, no changes being made to the protocol when moving from the small, developmental scale to larger scales. In some cases reactions were scaled over 18,000-fold when moving from small (0.1−1 mmol) to large (1−18 mol) runs.
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