ReactIR Flow Cell: A New Analytical Tool for Continuous Flow Chemical Processing
Organic Process Research & Development2010Vol. 14(2), pp. 393–404
Citations Over TimeTop 1% of 2010 papers
Catherine F. Carter, Heiko Lange, Steven V. Ley, Ian R. Baxendale, Brian Wittkamp, Jon G. Goode, Nigel L. Gaunt
Abstract
A newly developed ReactIR flow cell is reported as a convenient and versatile inline analytical tool for continuous flow chemical processing. The flow cell, operated with ATR technology, is attached directly into a reaction flow stream using standard OmniFit (HPLC) connections and can be used in combination with both meso- and microscale flow chemistry equipment. The iC IR analysis software (version 4.0) enables the monitoring of reagent consumption and product formation, aiding the rapid optimisation of procedures. Short-lived reactive intermediates can also be observed in situ, giving further mechanistic insight into complex transformations.
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