Improved Stereoselective Synthesis of the β-Anomer of 1-[3,5-Bis-O-(p-chlorobenzoyl)-2-deoxy-d-ribofuranosyl]-5-iodo-2-pyrimidinone
Organic Process Research & Development1999Vol. 3(2), pp. 135–138
Abstract
The lack of stereochemical control has been a major hurdle in synthesizing β-nucleosides in large scale. This paper reports a study of the effects of different catalysts used in the synthesis of β-nucleosides. The effects of time and temperature on α- and β-anomers are illustrated in this paper. The yield and selectivity of the β-nucleoside have been improved vastly at temperatures between −30 and −40 °C and by using SnCl4 as the catalyst.
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