Synthesis of CMI-977, a Potent 5-Lipoxygenase Inhibitor
Organic Process Research & Development1998Vol. 3(1), pp. 73–76
Citations Over Time
Xiong Cai, Mukund S. Chorghade, Aberra Fura, Gurmit Grewal, Karen A. Jauregui, Heather Lounsbury, Ralph T. Scannell, C. Grace Yeh, Michelle Young, Shaoxia Yu, Liang Guo, Robert M. Moriarty, Raju Penmasta, Munagala S. Rao, Rajesh Kumar Singhal, Zhengzhe Song, James P. Staszewski, Sudersan M. Tuladhar, Sanmin Yang
Abstract
CMI-977 is a potent 5-lipoxygenase inhibitor that intervenes in the production of leukotrienes and is presently being developed for the treatment of chronic asthma. It is a single enantiomer with an all-trans (2S,5S) configuration. Of the four isomers of CMI-977, the S,S isomer was found to have the best biological activity and was selected for further development. The enantiomerically pure product was synthesized on a 2-kg scale from (S)-(+)-hydroxymethyl-γ-butyrolactone.
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