Structural and Functional Properties of IL-4δ2, an Alternative Splice Variant of Human IL-4
Journal of Proteome Research2003Vol. 2(3), pp. 273–281
Citations Over TimeTop 24% of 2003 papers
Anatoly M. Vasiliev, Raisa N. Vasilenko, Nataly L. Kulikova, Sergey Andreev, Irina O. Chikileva, Galina Yu. Puchkova, Igor V. Kosarev, Anna V. Khodyakova, В. С. Хлебников, L. R. Ptitsyn, Grygory Ya. Shcherbakov, Vladimir N. Uversky, L. DuBuske, Vyacheslav M. Abramov
Abstract
Structural and functional properties of recombinant IL-4delta2, a naturally occurring splice variant of human IL-4 with a deletion of the loop region 22-37, have been analyzed. IL-4delta2 has alpha-helical structure and most likely preserves the "up-up-down-down" topology typical of the four-helix-bundle cytokines. IL-4delta2 interacts specifically with the alpha chain of IL-4R and competes effectively with IL-4 for the common binding sites. Thus, IL-4delta2 may act as a regulator of the cytokine net, being the natural antagonist of IL-4.
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