Proteomic Characterization of Midproliferative and Midsecretory Human Endometrium
Journal of Proteome Research2009Vol. 8(4), pp. 2032–2044
Citations Over TimeTop 10% of 2009 papers
Jenny I.-C. Chen, Natalie J. Hannan, Yunxian Mak, Peter K. Nicholls, Jin Zhang, Adam Rainczuk, Peter G. Stanton, David Robertson, Lois A. Salamonsen, Andrew N. Stephens
Abstract
This study aimed to identify proteins differentially expressed in the human endometrium between the proliferative and secretory phases of normal menstrual cycles by 2D differential in-gel electrophoresis (DIGE). A total of 196 out of 1017 spots were differentially expressed (p < 0.05). Mass spectrometry identified 76 proteins representing 41 different gene products. Immunohistochemistry confirmed the observed changes in 3 representative proteins (Rho-GDIalpha, CLIC1, PGRMC1). Biological pathway analysis identified the Jnk and EGF signaling pathways as key regulators of protein expression in the midsecretory phase of endometrial proteome.
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