Allosteric Behavior in Cytochrome P450-Dependent in Vitro Drug−Drug Interactions: A Prospective Based on Conformational Dynamics

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Abstract

ADVERTISEMENT RETURN TO ISSUEPREVPerspectiveNEXTAllosteric Behavior in Cytochrome P450-Dependent in Vitro Drug−Drug Interactions: A Prospective Based on Conformational DynamicsWilliam M. Atkins, Regina W. Wang, and Anthony Y. H. LuView Author Information Department of Medicinal Chemistry, University of Washington, Seattle, Washington 98195, Department of Drug Metabolism, Merck Research Laboratories, Rahway, New Jersey 07065, and Laboratory for Cancer Research, College of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854 Cite this: Chem. Res. Toxicol. 2001, 14, 4, 338–347Publication Date (Web):March 8, 2001Publication History Received5 October 2000Published online8 March 2001Published inissue 1 April 2001https://doi.org/10.1021/tx0002132Copyright © 2001 American Chemical SocietyRequest reuse permissionsArticle Views398Altmetric-Citations87LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit Read OnlinePDF (118 KB) Get e-AlertscloseSUBJECTS:Kinetic modeling,Kinetics,Ligands,Molecular structure,Peptides and proteins Get e-Alerts

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