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Coumarin mercapturic acid isolated from rat urine indicates metabolic formation of coumarin 3,4-epoxide
Chemical Research in Toxicology1991Vol. 4(5), pp. 586–590
Citations Over TimeTop 11% of 1991 papers
Abstract
A coumarin mercapturic acid, N-acetyl-S-(3-coumarinyl)cysteine, has been identified in the urine of coumarin-treated rats. [14C]Coumarin was applied by gavage as a single dose to male Wistar rats (10-150 mg/kg body weight). Twenty-four-hour urine was collected, and the deproteinized concentrate was analyzed for radiolabeled metabolites by HPLC. The new mercapturic acid metabolite is supposed to result from oxidative biotransformation of coumarin to its 3,4-epoxide and subsequent coupling with glutathione.
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