Skin Sensitization: Reaction Mechanistic Applicability Domains for Structure−Activity Relationships
Citations Over TimeTop 1% of 2005 papers
Abstract
The prediction of skin sensitization potential with minimum animal testing is currently of great importance in light of forthcoming legislation. A number of structure-activity relationships for skin sensitization have been published over the years, but their applicability has often been limited to structural classes. The concept of an applicability domain for a quantitative structure-activity relationship [(Q)SAR] is increasingly being viewed as key for the predictive application of (Q)SARs. This is particularly the case for skin sensitization if more widely applicable SARs are to be developed. In this paper, we analyze a recently published chemical data set for skin sensitization, apply reaction mechanistic criteria to domain classification, and evaluate the structure-activity trends observed within each of these mechanistic domains.
Related Papers
- → Probabilistic derivation of the interspecies assessment factor for skin sensitization(2017)15 cited
- → Skin Sensitization Evaluation of Carbon-Based Graphene Nanoplatelets(2021)14 cited
- → Dinitrohalobenzenes: evaluation of relative skin sensitization potential using the local lymph node assay(1997)43 cited
- The skin sensitization potential of four alkylalkanolamines.(1998)
- → The Evaluation of Potential Skin Sensitization and Collagen Synthesis of Rats Receiving Proteoglycan Serum(2018)2 cited