Stereostructure and Biological Activity of 42-Hydroxy-palytoxin: A New Palytoxin Analogue from HawaiianPalythoaSubspecies
Chemical Research in Toxicology2009Vol. 22(11), pp. 1851–1859
Citations Over TimeTop 10% of 2009 papers
Patrizia Ciminiello, Carmela Dell’Aversano, Emma Dello Iacovo, Ernesto Fattorusso, Martino Forino, Laura Grauso, Luciana Tartaglione, Chiara Florio, Paola Lorenzon, Marco Bortoli, Aurelia Tubaro, Mark Poli, Gary S. Bignami
Abstract
This paper reports on the analysis of the toxin content from Palythoa tuberculosa and Palythoa toxica samples collected off of the Hawaiian coast. Our work, based on in-depth high-resolution liquid chromatography-mass spectrometry analysis along with extensive NMR study, led us to structurally characterize 42-hydroxy-palytoxin, a new palytoxin congener. This toxin and palytoxin itself appeared to be the major components of toxic extract from a P. tuberculosa sample, while 42-hydroxy-palytoxin was proven by far to be the main palytoxin derivative in P. toxica. Functional studies on this new palytoxin-like compound suggest that the new palytoxin analogue and palytoxin itself present similar biological activities.
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