Nuclear-targeting TAT-PEG-Asp8-doxorubicin polymeric nanoassembly to overcome drug-resistant colon cancer
Acta Pharmacologica Sinica2016Vol. 37(8), pp. 1110–1120
Citations Over TimeTop 22% of 2016 papers
Zhenzhen Pan, Huiyuan Wang, Meng Zhang, Tingting Lin, Wenyuan Zhang, Pengfei Zhao, Yisi Tang, Yong Xiong, Zeng Yuan-er, Yongzhuo Huang
Abstract
TAT-PEG-Asp8-Dox NPs can increase cellular drug uptake and intranuclear drug delivery and retain effective drug accumulation inside the cells, thus exhibiting enhanced anticancer activity toward the drug-resistant human colon cancer HCT8/ADR cells.
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