A multi-centre randomised phase III trial of Dexamethasone vs Dexamethasone and diethylstilbestrol in castration-resistant prostate cancer: immediate vs deferred Diethylstilbestrol
British Journal of Cancer2011Vol. 104(4), pp. 620–628
Citations Over TimeTop 10% of 2011 papers
Jonathan Shamash, Thomas Powles, Shah Jalal Sarker, Andrew Protheroe, Natasha Mithal, Robert Mills, Ralph Beard, Peter Wilson, N. L. Tranter, Neale O’Brien, Siobhan McFaul, R.T.D. Oliver
Abstract
Dexamethasone and immediate Diethylstilbestrol resulted in neither higher PSA response rate nor higher PFS compared with Dexamethasone with deferred Diethylstilbestrol. There was no suggestion of significantly improved overall survival or quality of life. Given the significantly higher toxicity of Diethylstilbestrol, deferring Diethylstilbestrol until failure of Dexamethasone is the preferred strategy when using these agents in CRPC.
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