Patterns of genomic loss of heterozygosity predict homologous recombination repair defects in epithelial ovarian cancer
British Journal of Cancer2012Vol. 107(10), pp. 1776–1782
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Victor Abkevich, Kirsten M. Timms, Bryan T. Hennessy, Jennifer Potter, Mark Carey, Lisa Meyer, Karen Smith‐McCune, Russell Broaddus, K.H. Lu, J Chen, Thuan Van Tran, Deniece R. Williams, Diana Iliev, Srikanth Jammulapati, Liesel M. FitzGerald, Thomas C. Krivak, Julie A. DeLoia, Alexander Gutin, Gordon B. Mills, J. S. Lanchbury
Abstract
The HRD score appears capable of detecting homologous recombination defects regardless of aetiology or mechanism. This score could facilitate the use of PARP inhibitors and platinum in breast, ovarian, and other cancers.
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