ZEB1 turns into a transcriptional activator by interacting with YAP1 in aggressive cancer types

Citations Over TimeTop 1% of 2016 papers

Abstract

Early dissemination, metastasis and therapy resistance are central hallmarks of aggressive cancer types and the leading cause of cancer-associated deaths. The EMT-inducing transcriptional repressor ZEB1 is a crucial stimulator of these processes, particularly by coupling the activation of cellular motility with stemness and survival properties. ZEB1 expression is associated with aggressive behaviour in many tumour types, but the potent effects cannot be solely explained by its proven function as a transcriptional repressor of epithelial genes. Here we describe a direct interaction of ZEB1 with the Hippo pathway effector YAP, but notably not with its paralogue TAZ. In consequence, ZEB1 switches its function to a transcriptional co-activator of a 'common ZEB1/YAP target gene set', thereby linking two pathways with similar cancer promoting effects. This gene set is a predictor of poor survival, therapy resistance and increased metastatic risk in breast cancer, indicating the clinical relevance of our findings.

Related Papers

• → Mammalian Tead proteins regulate cell proliferation and contact inhibition as transcriptional mediators of Hippo signaling(2008)394 cited
• → Molecular Mechanism of Hippo–YAP1/TAZ Pathway in Heart Development, Disease, and Regeneration(2020)67 cited
• → The mammalian Hippo pathway: regulation and function of YAP1 and TAZ(2014)107 cited
• → High Yes-associated protein 1 with concomitant negative LATS1/2 expression is associated with poor prognosis of advanced gastric cancer(2019)22 cited
• Mammalian Tead proteins regulate cell proliferation and contact inhibition as transcriptional mediators of Hippo signaling(2008)