Simultaneous optical and electrical in vivo analysis of the enteric nervous system
Nature Communications2016Vol. 7(1), pp. 11800–11800
Citations Over TimeTop 10% of 2016 papers
Nikolai Rakhilin, Bradley B. Barth, Jiahn Choi, Nini Muñoz, Subhash Kulkarni, Jason S. Jones, David M. Small, Yu‐Ting Cheng, Yingqiu Cao, Colleen LaVinka, Edwin C. Kan, Xinzhong Dong, Michael G. Spencer, Pankaj J. Pasricha, Nozomi Nishimura, Xiling Shen
Abstract
The enteric nervous system (ENS) is a major division of the nervous system and vital to the gastrointestinal (GI) tract and its communication with the rest of the body. Unlike the brain and spinal cord, relatively little is known about the ENS in part because of the inability to directly monitor its activity in live animals. Here, we integrate a transparent graphene sensor with a customized abdominal window for simultaneous optical and electrical recording of the ENS in vivo. The implanted device captures ENS responses to neurotransmitters, drugs and optogenetic manipulation in real time.
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