Innate scavenger receptor-A regulates adaptive T helper cell responses to pathogen infection
Citations Over TimeTop 11% of 2017 papers
Abstract
The pattern recognition receptor (PRR) scavenger receptor class A (SR-A) has an important function in the pathogenesis of non-infectious diseases and in innate immune responses to pathogen infections. However, little is known about the role of SR-A in the host adaptive immune responses to pathogen infection. Here we show with mouse models of helminth Schistosoma japonicum infection and heat-inactivated Mycobacterium tuberculosis stimulation that SR-A is regulated by pathogens and suppresses IRF5 nuclear translocation by direct interaction. Reduced abundance of nuclear IRF5 shifts macrophage polarization from M1 towards M2, which subsequently switches T-helper responses from type 1 to type 2. Our study identifies a role for SR-A as an innate PRR in regulating adaptive immune responses.
Related Papers
- → Bacterial and fungal pattern recognition receptors in homologous innate signaling pathways of insects and mammals(2015)131 cited
- → Cytosolic DNA recognition for triggering innate immune responses(2008)89 cited
- → The Innate Immune System(2007)
- Progress on Peptidoglycan Recognition Proteins in Innate Immune System(2014)
- Innate Immune Recognition of the Pathogenic Fungus by Toll-Like Receptors(2012)