A graphene field-effect transistor as a molecule-specific probe of DNA nucleobases
Citations Over TimeTop 10% of 2015 papers
Abstract
Fast and reliable DNA sequencing is a long-standing target in biomedical research. Recent advances in graphene-based electrical sensors have demonstrated their unprecedented sensitivity to adsorbed molecules, which holds great promise for label-free DNA sequencing technology. To date, the proposed sequencing approaches rely on the ability of graphene electric devices to probe molecular-specific interactions with a graphene surface. Here we experimentally demonstrate the use of graphene field-effect transistors (GFETs) as probes of the presence of a layer of individual DNA nucleobases adsorbed on the graphene surface. We show that GFETs are able to measure distinct coverage-dependent conductance signatures upon adsorption of the four different DNA nucleobases; a result that can be attributed to the formation of an interface dipole field. Comparison between experimental GFET results and synchrotron-based material analysis allowed prediction of the ultimate device sensitivity, and assessment of the feasibility of single nucleobase sensing with graphene.
Related Papers
- → The effect of substrates on the Raman spectrum of graphene: Graphene- on-sapphire and graphene-on-glass(2007)250 cited
- → Orthotropic friction at the edges and interior of graphene and graphene fluoride and frictional anisotropy of graphene at the nanoscale(2021)1 cited
- A natural advantage? Using mined graphite to make graphene(2013)
- Synthesis and Characterisation of Graphene Single Sheets(2012)
- Unique synthesis of graphene-based materials for clean energy and biological sensing applications(2012)